Before the 2020 Artsakh War, the Tufenkian Foundation undertook the restoration of several significant historic sites across the region. These included the St. Minas Church (17th century, village of Hak), the St. Asdvadsatsin Church (17th century, village of Mirik), and St. Stepanos Church (17th century, village of Hochants), as well as the refectory of the medieval Dadivank Monastery (9th–13th centuries), a historic khan (inn) near the Hellenistic ruins of Tigranakert, and the mid-19th century building that once housed the Shushi Historical Museum.

In the weeks following the November 9, 2020 ceasefire agreement, the Tufenkian Foundation joined an urgent effort to document Armenian cultural monuments in territories set to pass under Azerbaijani control. Teams worked rapidly to capture these sites through photography, photogrammetry, and 3D laser scanning — creating lasting records of heritage that could no longer be physically protected. Today, the Foundation continues this work in partnership with multiple organisations, monitoring the condition of these and other monuments through satellite observation and remote sensing technology, ensuring that the fate of Armenian cultural heritage in Artsakh remains visible to the world.